Distribution, Biotransformation, Pharmacological Effects, Metabolic Mechanism and Safety Evaluation of Platycodin D: A Comprehensive Review.

Platycodonis Radix (Jiegeng), the dried root of Platycodon grandiflorum, is a traditional herb used as both medicine and food. Its clinical application for the treatment of cough, phlegm, sore throat, pulmonary and respiratory diseases has been thousands of years in China. Platycodin D is the main active ingredient in Platycodonis Radix, which belongs to the family of pentacyclic triterpenoid saponins because it contains an oleanolane type aglycone linked with double sugar chains. Modern pharmacology has demonstrated that Platycodin D displays various biological activities, such as analgesics, expectoration and cough suppression, promoting weight loss, anti-tumor and immune regulation, suggesting that Platycodin D has the potential to be a drug candidate and an interesting target as a natural product for clinical research. In this review, the distribution and biotransformation, pharmacological effects, metabolic mechanism and safety evaluation of Platycodin D are summarized to lay the foundation for further studies.

Impacts of the meteorological condition versus emissions reduction on the PM2.5 concentration over Beijing–Tianjin–Hebei during the COVID-19 lockdown

The impacts of the meteorological condition and emissions reduction on the aerosol concentration over the Beijing–Tianjin–Hebei (BTH) region during the COVID-19 lockdown were analyzed by conducting three numerical experiments, including one with the meteorological field in 2019 and MEIC-2019 (2019 monthly Multi-resolution Emissions Inventory for China), one with the meteorological field in 2020 and MEIC-2019, and one with the meteorological field in 2020 and MEIC-2020, via a WRF-Chem model. The numerical experiments were performed from 3–16 February in 2019 and in 2020, during which a severe fog–haze event (3–16 February 2020) occurred in the BTH region, with a simulated maximum daily PM2.5 of 245 μg m−3 in Tangshan and 175 μg m−3 in Beijing. The results indicate that the daily PM2.5 decreased by 5–150 μg m−3 due to the emissions reduction and increased by 10–175 μg m−3 due to the meteorological condition in Beijing, Shijiazhuang, Cangzhou, Handan, Hengshui, Chengde, Zhangjiakou, and Tangshan from 7–14 February. For the horizontal distribution, PM2.5 and different aerosol species concentrations from 7–14 February 2020 increased compared with those during the same period in 2019, indicating that the accumulation of pollutants caused by the unfavorable meteorological condition offset the decreases caused by the emissions reduction, leading to the high aerosol concentration during the COVID-19 lockdown. 摘要 本研究从气象条件和减排两方面探讨了COVID-19封锁期间严重雾霾发生的原因[研究目的], 并定量的分析了气象条件和减排对PM2.5浓度的相对影响[创新点].使用WRF-Chem在2019年2月3日–16日和2020年2月3日–16日进行了三个数值模拟试验, 分别为2019年气象场与MEIC-2019 (2019年中国多分辨率月度排放清单) ,2020年气象场与MEIC-2019,2020年气象场与MEIC-2020[研究方法].结果表明COVID-19封锁期间严重雾霾的原因是不利气象条件增加的PM2.5浓度大于减排减少的PM2.5浓度[重要结论].